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Título: | Evolution of the melanocortin system |
Autor: | Cortés, Raúl CSIC ORCID; Navarro, Sandra CSIC; Agulleiro Gozalbo, Maria Josep CSIC ORCID; Guillot, Raúl CSIC ORCID; García-Herranz, Víctor CSIC; Sánchez Martínez, Elisa CSIC ORCID ; Cerdá-Reverter, José Miguel CSIC ORCID CVN | Palabras clave: | AGRP ACTH MRAP AGOUTI POMC MSH |
Fecha de publicación: | dic-2014 | Editor: | Elsevier | Citación: | General and Comparative Endocrinology 209: 3-10 (2014) | Resumen: | The melanocortin system is one of the most complex of the hormonal systems. It involves different agonists encoded in the multiplex precursor proopiomelanocortin (POMC) or in different genes as β-defensins, endogenous antagonist, like agouti-signalling protein (ASIP) or agouti-related protein (AGRP), and five different melanocortin receptors (MCRs). Rounds of whole genome duplication events have preceded the functional and molecular diversification of the family in addition some co-evolutionary and tandem duplication processes have been proposed. The evolutionary patterns of the different partners are controversial and different hypotheses have emerged from a study of the sequenced genomes. In this review, we summarize the different evolutionary hypotheses proposed for the different melanocortin partners. © 2014 Elsevier Inc. | Versión del editor: | https://doi.org/10.1016/j.ygcen.2014.04.005 | URI: | http://hdl.handle.net/10261/144147 | DOI: | 10.1016/j.ygcen.2014.04.005 | Identificadores: | issn: 1095-6840 |
Aparece en las colecciones: | (IATS) Artículos |
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