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http://hdl.handle.net/10261/142739
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dc.contributor.author | den Exter, Paul L. | - |
dc.contributor.author | Gómez, Vicente | - |
dc.contributor.author | Jiménez, David | - |
dc.contributor.author | Trujillo-Santos, Javier | - |
dc.contributor.author | Muriel, Alfonso | - |
dc.contributor.author | Huisman, Menno V. | - |
dc.contributor.author | Monreal, Manuel | - |
dc.date.accessioned | 2017-01-19T11:09:22Z | - |
dc.date.available | 2017-01-19T11:09:22Z | - |
dc.date.issued | 2013-01 | - |
dc.identifier | issn: 0012-3692 | - |
dc.identifier | e-issn: 1931-3543 | - |
dc.identifier.citation | Chest 173(1): 138–145 (2013) | - |
dc.identifier.uri | http://hdl.handle.net/10261/142739 | - |
dc.description.abstract | [Background] Physicians need a specific risk-stratification tool to facilitate safe and cost-effective approaches to the management of patients with cancer and acute pulmonary embolism (PE). The objective of this study was to develop a simple risk score for predicting 30-day mortality in patients with PE and cancer by using measures readily obtained at the time of PE diagnosis. | - |
dc.description.abstract | [Methods] Investigators randomly allocated 1,556 consecutive patients with cancer and acute PE from the international multicenter Registro Informatizado de la Enfermedad TromboEmbólica to derivation (67%) and internal validation (33%) samples. The external validation cohort for this study consisted of 261 patients with cancer and acute PE. Investigators compared 30-day all-cause mortality and nonfatal adverse medical outcomes across the derivation and two validation samples. | - |
dc.description.abstract | [Results] In the derivation sample, multivariable analyses produced the risk score, which contained six variables: age > 80 years, heart rate ≥ 110/min, systolic BP < 100 mm Hg, body weight < 60 kg, recent immobility, and presence of metastases. In the internal validation cohort (n = 508), the 22.2% of patients (113 of 508) classified as low risk by the prognostic model had a 30-day mortality of 4.4% (95% CI, 0.6%–8.2%) compared with 29.9% (95% CI, 25.4%–34.4%) in the high-risk group. In the external validation cohort, the 18% of patients (47 of 261) classified as low risk by the prognostic model had a 30-day mortality of 0%, compared with 19.6% (95% CI, 14.3%–25.0%) in the high-risk group. | - |
dc.description.abstract | [Conclusions] The developed clinical prediction rule accurately identifies low-risk patients with cancer and acute PE. | - |
dc.description.sponsorship | We are grateful to Sanofi Spain for supporting this registry with an unrestricted educational grant. We are also grateful to Bayer Pharma AG for supporting this registry. Bayer Pharma AG's support was limited to the part of RIETE outside Spain, which accounts for 15.53% of the total patients included in the RIETE Registry. | - |
dc.publisher | Elsevier | - |
dc.rights | closedAccess | - |
dc.title | A clinical prognostic model for the identification of low-risk patients with acute symptomatic pulmonary embolism and active cancer | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1378/chest.12-0964 | - |
dc.relation.publisherversion | http://doi.org/10.1378/chest.12-0964 | - |
dc.date.updated | 2017-01-19T11:09:22Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Bayer | - |
dc.contributor.funder | Sanofi España | - |
dc.relation.csic | No | - |
dc.identifier.funder | http://dx.doi.org/10.13039/100004326 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
item.fulltext | No Fulltext | - |
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