Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/135558
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | CXCR4 expression enhances diffuse large B cell lymphoma dissemination and decreases patient survival |
Autor: | Moreno, María José; Alcoceba, Miguel; Blanco, Óscar; González, Marcos CSIC ORCID ; Mangues, Ramon; Casanova, Isolda | Palabras clave: | CXCR4 Cell dissemination Prognostic marker Cell migration Diffuse large B cell lymphoma |
Fecha de publicación: | 2015 | Editor: | John Wiley & Sons | Citación: | Journal of Pathology 235(3): 445-455 (2015) | Resumen: | The chemokine receptor CXCR4 has been implicated in the migration and trafficking of malignant B cells in several haematological malignancies. Over-expression of CXCR4 has been identified in haematological tumours, but data concerning the role of this receptor in diffuse large B cell lymphoma (DLBCL) are lacking. CXCR4 is a marker of poor prognosis in various neoplasms, correlating with metastatic disease and decreased survival of patients. We studied CXCR4 involvement in cell migration in vitro and dissemination in vivo. We also evaluated the prognostic significance of CXCR4 in 94 biopsies of DLBCL patients. We observed that the level of expression of CXCR4 in DLBCL cell lines correlated positively with in vitro migration. Expression of the receptor was also associated with increased engraftment and dissemination, and decreased survival time in NOD/SCID mice. Furthermore, administration of a specific CXCR4 antagonist, AMD3100, decreased dissemination of DLBCL cells in a xenograft mouse model. In addition, we found that CXCR4 expression is an independent prognostic factor for shorter overall survival and progression-free survival in DLBCL patients. These results show that CXCR4 mediates dissemination of DLBCL cells and define for the first time its value as an independent prognostic marker in DLBCL patients. | URI: | http://hdl.handle.net/10261/135558 | DOI: | 10.1002/path.4446 | Identificadores: | doi: 10.1002/path.4446 e-issn: 1096-9896 issn: 0022-3417 |
Aparece en las colecciones: | (IBMCC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
67
checked on 25-abr-2024
WEB OF SCIENCETM
Citations
63
checked on 27-feb-2024
Page view(s)
246
checked on 26-abr-2024
Download(s)
124
checked on 26-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.