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Título: | Effect of oncoxin oral solution in HER2-overexpressing breast cancer |
Autor: | Hernández-García, Susana CSIC; González, Verena CSIC; Sanz, Eduardo; Pandiella, Atanasio CSIC ORCID CVN | Fecha de publicación: | 2015 | Editor: | Taylor & Francis | Citación: | Nutrition and Cancer 67(7): 1159-1169 (2015) | Resumen: | One of the most aggressive breast cancer subtypes includes tumors with high expression of HER2. Gene expression and functional studies have shown a link between HER2 overexpression and oxidative stress. Because of this, we hypothesized that Oncoxin Oral Solution (OOS), a composite product that contains several antioxidants, could have an antitumoral effect against HER2+ tumors. Dose-response studies, biochemical and cytometric assessment of the effect of OOS on cell cycle and apoptosis, and drug combination analyses were performed on BT474 and SKBR3 cells, 2 HER2-overexpressing breast cancer cell lines. OOS reduced the proliferation of these cells, and augmented the action of lapatinib, a HER2 inhibitor used in the breast cancer clinic. Moreover, OOS decreased growth of HER2+ tumors in mice. Mechanistically, OOS provoked cell cycle blockade through upregulation of p27 expression and downregulation of cyclin D levels. OOS also caused apoptotic cell death in HER2+ breast cancer cells, as indicated by increases in PARP cleavage as well as upregulation of caspase 8 and caspase 3 activities. These results demonstrate an antitumoral action of OOS in preclinical models of HER2+ breast cancer and suggest that it can be used with anti-HER2 therapies currently adopted as standard of care in the oncology clinic. | URI: | http://hdl.handle.net/10261/134802 | DOI: | 10.1080/01635581.2015.1068819 | Identificadores: | doi: 10.1080/01635581.2015.1068819 e-issn: 1532-7914 issn: 0163-5581 |
Aparece en las colecciones: | (IBMCC) Artículos |
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