Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/134632
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | The HSP90 inhibitor 17-AAG potentiates the antileishmanial activity of the ether lipid edelfosine |
Autor: | Varela-M, Rubén E.; Mollinedo-Gajate, Cristina; Muro, Antonio; Mollinedo, Faustino CSIC ORCID | Palabras clave: | Apoptosis-like cell death Cell cycle arrest Edelfosine 17-AAG HSP90 inhibitor Leishmania spp. |
Fecha de publicación: | mar-2014 | Editor: | Elsevier | Citación: | Acta Tropica 131: 32-36 (2014) | Resumen: | HSP90 is an abundant protein in Leishmania parasites that plays a major role in the parasite survival under stress conditions. Here we found that the HSP90 inhibitor 17-AAG (≥100nM 17-AAG) induced cell cycle arrest at G0/G1 in Leishmania infantum and Leishmania panamensis promastigotes, and highly potentiated the induction of cell death by an apoptotic-like process mediated by the ether phospholipid edelfosine (5-20μM). These data suggest that the combined treatment of 17-AAG and edelfosine might be a novel and effective approach of combination therapy in the treatment of leishmaniasis. | Versión del editor: | http://dx.doi.org/10.1016/j.actatropica.2013.11.018 | URI: | http://hdl.handle.net/10261/134632 | DOI: | 10.1016/j.actatropica.2013.11.018 | Identificadores: | issn: 0001-706X e-issn: 1873-6254 |
Aparece en las colecciones: | (IBMCC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
HSP90_inhibitor_Varela.pdf | 418,03 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
10
checked on 24-abr-2024
WEB OF SCIENCETM
Citations
9
checked on 25-feb-2024
Page view(s)
215
checked on 26-abr-2024
Download(s)
405
checked on 26-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.