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Título: | Whole-exome sequencing in splenic marginal zone lymphoma reveals mutations in genes involved in marginal zone differentiation |
Autor: | Vaqué, José P. CSIC ORCID; Varela, Ignacio CSIC ORCID; Piris, Miguel A. | Fecha de publicación: | 2014 | Editor: | Nature Publishing Group | Citación: | Leukemia 28: 1334-1340 (2014) | Resumen: | Splenic marginal zone lymphoma (SMZL) is a B-cell neoplasm whose molecular pathogenesis remains fundamentally unexplained, requiring more precise diagnostic markers. Previous molecular studies have revealed 7q loss and mutations of nuclear factor κB (NF-κB), B-cell receptor (BCR) and Notch signalling genes. We performed whole-exome sequencing in a series of SMZL cases. Results confirmed that SMZL is an entity distinct from other low-grade B-cell lymphomas, and identified mutations in multiple genes involved in marginal zone development, and others involved in NF-κB, BCR, chromatin remodelling and the cytoskeleton. | URI: | http://hdl.handle.net/10261/130551 | DOI: | 10.1038/leu.2013.365 | Identificadores: | doi: 10.1038/leu.2013.365 e-issn: 1476-5551 issn: 0887-6924 |
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