Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/127846
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | MAP4K3 is a component of the TORC1 signalling complex that modulates cell growth and viability in Drosophila melanogaster |
Autor: | Resnik-Docampo, Martín; Celis, Jesús M. de | Fecha de publicación: | 2011 | Editor: | Public Library of Science | Citación: | PLoS ONE 6 (2011) | Resumen: | Background: MAP4K3 is a conserved Ser/Thr kinase that has being found in connection with several signalling pathways, including the Imd, EGFR, TORC1 and JNK modules, in different organisms and experimental assays. We have analyzed the consequences of changing the levels of MAP4K3 expression in the development of the Drosophila wing, a convenient model system to characterize gene function during epithelial development. Methodology and Principal Findings: Using loss-of-function mutants and over-expression conditions we find that MAP4K3 activity affects cell growth and viability in the Drosophila wing. These requirements are related to the modulation of the TORC1 and JNK signalling pathways, and are best detected when the larvae grow in a medium with low protein concentration (TORC1) or are exposed to irradiation (JNK). We also show that MAP4K3 display strong genetic interactions with different components of the InR/Tor signalling pathway, and can interact directly with the GTPases RagA and RagC and with the multi-domain kinase Tor. Conclusions and Significance: We suggest that MAP4K3 has two independent functions during wing development, one related to the activation of the JNK pathway in response to stress and other in the assembling or activation of the TORC1 complex, being critical to modulate cellular responses to changes in nutrient availability. © 2011 Resnik-Docampo, de Celis. | URI: | http://hdl.handle.net/10261/127846 | DOI: | 10.1371/journal.pone.0014528 | Identificadores: | doi: 10.1371/journal.pone.0014528 issn: 1932-6203 |
Aparece en las colecciones: | (CBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Celis_JF MAP4K3IsaComponent.pdf | 5,2 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
16
checked on 05-may-2024
SCOPUSTM
Citations
23
checked on 03-may-2024
WEB OF SCIENCETM
Citations
19
checked on 28-feb-2024
Page view(s)
177
checked on 09-may-2024
Download(s)
203
checked on 09-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.