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Título: | Unfractionated heparin is associated with a lower rise of serum vascular cell adhesion molecule-1 in acute ischemic stroke patients |
Autor: | Chamorro, Ángel; Cervera, Álvaro; Castillo, José; Dávalos, Antoni; Aponte, John Jairo; Planas, Anna M. CSIC ORCID | Palabras clave: | Vascular cell adhesion molecule-1 Outcome Inflammation Heparin Cytokines Cerebrovascular disease spirin |
Fecha de publicación: | 16-ago-2002 | Editor: | Elsevier | Citación: | Neuroscience Letters 328(3): 229-232 (2002) | Resumen: | We sought to assess the anti-inflammatory properties of unfractionated heparin (UFH) in patients with ischemic stroke treated within 24 h from the onset of symptoms. We studied prospectively 167 patients that received 1000 IU/h intravenous UFH (n=70) or 300 mg oral aspirin (n=97) at a mean treatment delay of 6.7 h. Repeated plasma levels of interleukin (IL)-6, IL-10, IL-4, tumor necrosis factor (TNF)-α, soluble intercellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1) were compared in both groups using multivariate analyses. Whereas TNF-α and sICAM-1 decreased at 48 h, IL-6, IL-4, and sVCAM-1 increased compared with baseline values (P<0.01). The rise of sVCAM-1 levels at 48 h was significantly lower in patients treated with UFH (P=0.017) and a two-fold increase of baseline sVCAM-1 was an independent predictor of poor outcome (odds ratio, 2.19, 1.1-4.39). These results suggest that adjusted high-dose UFH has anti-inflammatory effects which might improve recovery if administered early after stroke onset. © 2002 Elsevier Science Ireland Ltd. All rights reserved. | Versión del editor: | http://dx.doi.org/10.1016/S0304-3940(02)00518-9 | URI: | http://hdl.handle.net/10261/116860 | DOI: | 10.1016/S0304-3940(02)00518-9 | Identificadores: | doi: 10.1016/S0304-3940(02)00518-9 issn: 0304-3940 |
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