Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/115532
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Premetazoan Origin of the Hippo Signaling Pathway |
Autor: | Sebé-Pedrós, Arnau CSIC ORCID; Zheng, Yonggang; Ruiz-Trillo, Iñaki CSIC ORCID ; Pan, Duojia | Fecha de publicación: | 26-ene-2012 | Editor: | Elsevier | Citación: | Cell Reports 1(1): 13-20 (2012) | Resumen: | Nonaggregative multicellularity requires strict control of cell number. The Hippo signaling pathway coordinates cell proliferation and apoptosis and is a central regulator of organ size in animals. Recent studies have shown the presence of key members of the Hippo pathway in nonbilaterian animals, but failed to identify this pathway outside Metazoa. Through comparative analyses of recently sequenced holozoan genomes, we show that Hippo pathway components, such as the kinases Hippo and Warts, the coactivator Yorkie, and the transcription factor Scalloped, were already present in the unicellular ancestors of animals. Remarkably, functional analysis of Hippo components of the amoeboid holozoan Capsaspora owczarzaki, performed in Drosophila melanogaster, demonstrate that the growth-regulatory activity of the Hippo pathway is conserved in this unicellular lineage. Our findings show that the Hippo pathway evolved well before the origin of Metazoa and highlight the importance of Hippo signaling as a key developmental mechanism predating the origin of Metazoa. © 2012 The Authors. | Versión del editor: | http://dx.doi.org/10.1016/j.celrep.2011.11.004 | URI: | http://hdl.handle.net/10261/115532 | DOI: | 10.1016/j.celrep.2011.11.004 | Identificadores: | doi: 10.1016/j.celrep.2011.11.004 issn: 2211-1247 |
Aparece en las colecciones: | (IBE) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
premetazoan_origin_Sebe.pdf | 1,1 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
65
checked on 25-abr-2024
SCOPUSTM
Citations
96
checked on 29-abr-2024
WEB OF SCIENCETM
Citations
92
checked on 28-feb-2024
Page view(s)
329
checked on 03-may-2024
Download(s)
277
checked on 03-may-2024