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http://hdl.handle.net/10261/11409
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Montero, Ana | - |
dc.contributor.author | Mann, Enrique | - |
dc.contributor.author | Chana López, Antonio | - |
dc.contributor.author | Herradón García, Bernardo | - |
dc.date.accessioned | 2009-03-09T16:10:23Z | - |
dc.date.available | 2009-03-09T16:10:23Z | - |
dc.date.issued | 2004-03-25 | - |
dc.identifier.citation | Chemistry & Biodiversity 1(3): 442-457 (2004) | en_US |
dc.identifier.issn | 1612-1872 | - |
dc.identifier.uri | http://hdl.handle.net/10261/11409 | - |
dc.description | 16 pages, 7 figures.-- PMID: 17191858 [PubMed].-- Taken in part from the Ph.D. thesis of A. C. (December, 2003) and the projected Ph.D. thesis of A. M. Spanish patent ES-P200301125 was filed as of Feb 16, 2006. | en_US |
dc.description.abstract | Calpain is a cysteine protease that is activated by Ca2+. The over-activation of calpain, which occurs on increasing Ca2+ concentration, causes a variety of diseases. This paper reports experimental results on the inhibition of calpain I (μ-calpain) by peptide-biphenyl hybrids. We have found that some peptide-biphenyl hybrids, with aromatic amino acids in the peptide chains, inhibit calpain with IC50 values in the nanomolar range. Since the peptide-biphenyl hybrids reported in the present paper do not posses a reactive electrophilic functionality, we hypothesize that they interfere with the activation of calpain by Ca2+, and present experimental and computational results on the binding of peptide-biphenyl hybrids to Ca2+. | en_US |
dc.description.sponsorship | Financial support from the Spanish Ministry of Science and Technology (project No. BQU2001-2270) and Fundación 'la Caixa' (project No. 02/162-02) is acknowledged. | en_US |
dc.format.extent | 88 bytes | - |
dc.format.mimetype | text/plain | - |
dc.language.iso | eng | en_US |
dc.publisher | John Wiley & Sons | en_US |
dc.rights | closedAccess | en_US |
dc.title | Peptide-biphenyl hybrids as calpain inhibitors | en_US |
dc.type | artículo | en_US |
dc.identifier.doi | 10.1002/cbdv.200490037 | - |
dc.description.peerreviewed | Peer reviewed | en_US |
dc.relation.publisherversion | http://dx.doi.org/10.1002/cbdv.200490037 | en_US |
dc.identifier.e-issn | 1612-1880 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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