Derechos | Preview | Fecha Public. | Título | Autor(es) | Tipo |
closedAccess | | 2013 | A therapeutic approach to cerebrovascular diseases based on indole substituted hydrazides and hydrazines able to interact with human vascular adhesion protein-1, monoamine oxidases (A and B), AChE and BuChE | Esteban, Gerard; Bolea, Irene; Sun, Ping; Solé, Montserrat CSIC ORCID ; Samadi, Abdelouahid CSIC ORCID; Marco-Contelles, José CSIC ORCID; Unzeta, Mercedes | artículo |
closedAccess | | 2013 | Analysis of the antioxidant properties of differently substituted 2- and 3-indolyl carbohydrazides and related derivatives | Hadjipavlou-Litina, Dimitra; Samadi, Abdelouahid CSIC ORCID; Unzeta, Mercedes; Marco-Contelles, José CSIC ORCID | artículo |
openAccess | | 28-jun-2016 | ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy | Marco-Contelles, José CSIC ORCID; Unzeta, Mercedes; Bolea, Irene; Esteban, Gerard; Ramsay, Rona R.; Romero Jódar, Alejandro CSIC ORCID; Martínez-Murillo, Ricardo CSIC ORCID; Carreiras, M. Carmo; Ismaili, L. | artículo |
closedAccess | | 26-feb-2015 | Catecholaminergic and cholinergic systems of mouse brain are modulated by LMN diet, rich in theobromine, polyphenols and polyunsaturated fatty acids | Fernández-Fernández, Laura; Valente, Tony; Unzeta, Mercedes | artículo |
closedAccess | | 2014 | Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease | Bautista-Aguilera, Óscar M. CSIC ORCID; Esteban, Gerard; Bolea, Irene; Nikolic, Katarina; Agbaba, Danica; Moraleda, Ignacio; Iriepa, Isabel; Samadi, Abdelouahid CSIC ORCID; Soriano, Elena CSIC; Unzeta, Mercedes; Marco-Contelles, José CSIC ORCID | artículo |
closedAccess | | 2014 | Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease | Wang, L.; Esteban, Gerard; Ojima, Masaki; Bautista-Aguilera, Óscar M. CSIC ORCID; Inokuchi, Tsutomu; Moraleda, Ignacio; Iriepa, Isabel; Samadi, Abdelouahid CSIC ORCID; Youdim, Moussa B. H.; Romero Jódar, Alejandro CSIC ORCID; Soriano, Elena CSIC; Herrero-Labrador, Raquel CSIC ORCID; Fernández Fernández, Ana Patricia CSIC; Martínez-Murillo, Ricardo CSIC ORCID; Marco-Contelles, José CSIC ORCID; Unzeta, Mercedes | artículo |
closedAccess | | 2014 | Effects of novel monoamine oxidases and cholinesterases targeting compounds on brain neurotransmitters and behavior in rat model of vascular dementia | Stasiak, Anna; Mussur, Miroslaw; Unzeta, Mercedes; Samadi, Abdelouahid CSIC ORCID; Marco-Contelles, José CSIC ORCID; Fogel, W. Agnieszka | artículo |
closedAccess | | 2014 | Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease | Esteban, Gerard; Allan, Jennifer; Samadi, Abdelouahid CSIC ORCID; Mattevi, Andrea; Unzeta, Mercedes; Marco-Contelles, José CSIC ORCID; Binda, Claudia; Ramsay, Rona R. | artículo |
openAccess | | 25-may-2016 | Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease | Unzeta, Mercedes; Esteban, Gerard; Bolea, Irene; Fogel, W. Agnieszka; Ramsay, Rona R.; Youdim, Moussa B. H.; Tipton, Keith Francis; Marco-Contelles, José CSIC ORCID | artículo |
openAccess | | 2014 | Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease: Design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids | Bautista-Aguilera, Óscar M. CSIC ORCID; Esteban, Gerard; Chioua, Mourad CSIC ORCID ; Nikolic, Katarina; Agbaba, Danica; Moraleda, Ignacio; Iriepa, Isabel; Soriano, Elena CSIC; Samadi, Abdelouahid CSIC ORCID; Unzeta, Mercedes; Marco-Contelles, José CSIC ORCID | artículo |
closedAccess | | 2013 | Multipotent, permeable drug ASS234 inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro | Bolea, Irene; Gella, Alejandro; Monjas, Leticia CSIC ORCID; Pérez, Concepción CSIC ORCID; Rodríguez-Franco, María Isabel CSIC ORCID ; Marco-Contelles, José CSIC ORCID; Samadi, Abdelouahid CSIC ORCID; Unzeta, Mercedes | artículo |
closedAccess | | 2014 | Neuroprotective effects of the MAO-B inhibitor, PF9601N, in an in vivo model of excitotoxicity | Bolea, Irene; Colivicchi, María Alessandra; Ballini, Chiara; Marco-Contelles, José CSIC ORCID; Tipton, Keith Francis; Unzeta, Mercedes; Della Corte, Laura | artículo |
openAccess | | 29-sep-2011 | Nuevos derivados de propargilamina con capacidad neuroprotectora para el tratamiento de las enfermedades de Alzheimer y Parkinson | Samadi, Abdelouahid CSIC ORCID; Marco-Contelles, José CSIC ORCID; Bolea Tomás, Irene; Luque, Francisco J.; Unzeta, Mercedes | solicitud de patente |
openAccess | | jun-2019 | Uric acid treatment after stroke modulates the Krüppel-like factor 2-VEGF-A axis to protect brain endothelial cell functions: Impact of hypertension | Vila, Elisabet; Solé, Montserrat CSIC ORCID ; Masip, Núria; Puertas-Umbert, Lídia; Amaro, Sergio; Dantas, Ana Paula; Unzeta, Mercedes; D'Ocón, Pilar; Planas, Anna M. CSIC ORCID; Chamorro, Ángel; Jiménez-Altayó, Francesc | artículo |