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Título

Determination of arsenic retention in immune system components by SR-µXRF and EDXRF. En el Capítulo: RADIACIÓN DE SINCROTRÓN, PIXE, AES, XPS

Autor Soria, Elio A.; Queralt Mitjans, Ignacio ; Perez, Roberto; Perez, Carlos A.; Bongiovanni, Guillermina A.
Fecha de publicación 2012
EditorUniversidad Autónoma de Puebla
Citación Análisis de materiales diversos por técnicas de rayos X: 155- 157 (2012)
ResumenArsenic (As) is an environmental contaminant which causes immune dysfunction by chronic exposure through contaminated drinking water. As has intestinal absorption and is widely transported by erythrocytes. In some cases, it is retained and accumulated, thus enhancing its toxic effects. However, there are no reports about As retention in lymphocytes. Although the plasmatic concentration of these cells is 500 times lower than red blood cells, a high number of lymphocytes are accumulated in certain tissues, called secondary lymphoid organs. One of them is the spleen, where B and T cells coexist in the white pulp, and erythrocytes mainly in the red pulp. To study spleen As retention as well as the effects on concentration and distribution of other elements, adult rats consumed water with 50 µg/L As for 60 days. Spleens were removed, then were cut into 0.5 mm slides and lyophilized. Slides were analyzed by SR-µXRF and EDXRF. A high concentration of As was found in lyophilized spleens (~50 µg/g ) in both white and red pulps in a similar extent, while a decrease of Cu and Fe was seen in treated animals. Therefore, these techniques allow determining the As distribution and the As-associated elemental alterations in rat splenic tissues.
URI http://hdl.handle.net/10261/99831
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