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Antiproliferative effect of alkylglycerols as vehicles of butyric acid on colon cancer cells

AuthorsMolina, Susana; Morán-Valero, María I. ; Martín, Diana ; Vázquez de Frutos, Luis ; Vargas, Teodoro; Torres, Carlos F. ; Ramírez de Molina, Ana; Reglero, Guillermo
Butyric acid
Lipid digestion
Lipid-delivery pro-drugs
Antiproliferative compounds
Issue Date2013
CitationChemistry and Physics of Lipids 175-176: 50-56 (2013)
AbstractThe anticarcinogenic activity of synthetic 1-O-octadecyl-2,3- dibutyroilglycerol (D-SCAKG) in tumor-cell line of colonocytes (SW620) was performed. The effect of the previously digested D-SCAKG under in vitro intestinal conditions was compared to the bioactivity of non-digested D-SCAKG. Antiproliferative activity of each individual product from digestion (1-O-octadecyl-2-butyroilglycerol; 1-O-octadecyl glycerol; butyric acid) was also performed. The impact of solubilization of lipid products within micellar structures was also tested. The 1-O-octadecyl glycerol was the most active compound, followed by 1-O-octadecyl-2-butyroilglycerol, D-SCAKG and butyric acid. The 1-O-octadecyl glycerol and butyric acid were the only molecules that showed antiproliferative effect in absence of micelles. Digested D-SCAKG was 4-fold more effective than non-digested D-SCAKG. A synergism between 1-O-octadecyl-2-butyroilglycerol and 1-O-octadecyl glycerol was evidenced. As summary, the synthetic D-SCAKG seems to be an interesting antitumoral lipid against colonocytes, especially after previous intestinal digestion, and mainly due to the synergism of the major products, namely 1-O-octadecyl-2- butyroilglycerol and 1-O-octadecyl glycerol. At the same time, 1-O-octadecyl-2-butyroilglycerol would constitute a stable esterified form of butyric acid for its vehiculization. © 2013 Published by Elsevier Ireland Ltd.
Publisher version (URL)http://dx.doi.org/10.1016/j.chemphyslip.2013.07.011
Identifiersdoi: 10.1016/j.chemphyslip.2013.07.011
issn: 0009-3084
e-issn: 1873-2941
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