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Título: | Global characterization and target identification of piRNAs and endo-siRNAs in mouse gametes and zygotes |
Autor: | García-López, Jesús CSIC; Hourcade, Juan D. CSIC; Alonso, Lola CSIC ORCID; Cárdenas, David B. CSIC; Del Mazo, Jesús CSIC ORCID | Palabras clave: | PiRNAs Endo-siRNAs Deep sequencing Transposable elements Germ cells Zygote |
Fecha de publicación: | jun-2014 | Editor: | Elsevier | Citación: | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2014,1839 ( 6) 463–475 | Resumen: | A set of small RNAs known as rasRNAs (repeat-associated small RNAs) have been related to the down-regulation of Transposable Elements (TEs) to safeguard genome integrity. Two key members of the rasRNAs group are piRNAs and endo-siRNAs. We have performed a comparative analysis of piRNAs and endo-siRNAs present in mouse oocytes, spermatozoa and zygotes, identified by deep sequencing and bioinformatic analysis. The detection of piRNAs and endo-siRNAs in the spermatozoa and revealed also in zygotes, hints to their potential delivery to oocytes during fertilization. However, a comparative assessment of the three cell types indicates that both piRNAs and endo-siRNAs are mainly maternally inherited. Finally, we have assessed the role of the different rasRNA molecules in connection with amplification processes by way of the "ping-pong cycle". Our results suggest that the ping-pong cycle can act on other rasRNAs, such as tRNA- and rRNA-derived fragments, thus not only being restricted to TEs during gametogenesis. © 2014 Elsevier B.V. | Descripción: | 44 p.-1 tab.-10 fig. | Versión del editor: | http://dx.doi.org/10.1016/j.bbagrm.2014.04.006 | URI: | http://hdl.handle.net/10261/99664 | DOI: | 10.1016/j.bbagrm.2014.04.006 | ISSN: | 1874-9399 |
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García-López et al _2014_BBA-GeneRegulatMech.pdf | 4,44 MB | Adobe PDF | Visualizar/Abrir |
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