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Título

Role of energy- and nutrient-sensing kinases AMP-activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in Adipocyte Differentiation

Autor Fernández-Veledo, Sonia; Vázquez Carballo, Ana; Vila-Bedmar, Rocío; Ceperuelo-Mallafré, Victoria; Vendrell, Joan
Palabras clave Adipogenesis
mTOR
White adipose tissue
Brown adipose tissue
Obesity
AMPK
Fecha de publicación 2013
EditorTaylor & Francis
Citación IUBMB Life 65: 572- 583 (2013)
ResumenRecent advances have demonstrated that the adipose tissue plays a central role in regulating overall energy balance. Obesity results from a chronic deregulation of energy balance, with energy intake exceeding energy expenditure. Recently, new mechanisms that control the obesity phenotype such as the equilibrium between white and brown adipose tissue function has been identified. In this context, it is becoming increasingly clear that in addition to cellular growth, AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) also regulate lipid metabolism and adipogenesis. Here, we review recent advances in the understanding of the molecular mechanisms involved in white and brown differentiation programs focusing on AMPK and mTOR signaling pathways, which may play differential roles in white adipose tissue and brown adipose tissue development. In view of the worldwide epidemic of obesity and its associated metabolic disorders such as insulin resistance and type 2 diabetes, targeting these kinases may represent a potential approach for reducing adiposity and improving obesity-related diseases. Copyright © 2013 International Union of Biochemistry and Molecular Biology, Inc.
URI http://hdl.handle.net/10261/99357
DOI10.1002/iub.1170
Identificadoresdoi: 10.1002/iub.1170
issn: 1521-6543
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