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Título: | The diamagnetic susceptibility of the tubulin dimer |
Autor: | Bras, W.; Torbet, J.; Diakun, Gregory P.; Rikken, G.L.J.A.; Díaz, José Fernando CSIC ORCID | Fecha de publicación: | 18-feb-2014 | Editor: | Hindawi Publishing Corporation | Citación: | Journal of Biophysics (2014) Article ID 985082, 5 pages | Resumen: | An approximate value of the diamagnetic anisotropy of the tubulin dimer, Δχdimer, has been determined assuming axial symmetry and that only the α-helices and β-sheets contribute to the anisotropy. Two approaches have been utilized: (a) using the value for the Δχα for an α-helical peptide bond given by Pauling (1979) and (b) using the previously determined anisotropy of fibrinogen as a calibration standard. The Δχdimer≈4×10-27 JT-2 obtained from these measurements are similar to within 20%. Although Cotton-Mouton measurements alone cannot be used to estimate Δχ directly, the value we measured, CMdimer=1.41±0.03×10-8 T-2cm2mg-1, is consistent with the above estimate for Δχdimer. The method utilized for the determination of the tubulin dimer diamagnetic susceptibility is applicable to other proteins and macromolecular assemblies as well. © 2014 Wim Bras et al. | Descripción: | 6 p.-1 fig. | Versión del editor: | http://dx.doi.org/10.1155/2014/985082 | URI: | http://hdl.handle.net/10261/99354 | DOI: | 10.1155/2014/985082 | ISSN: | 1687-8000 | E-ISSN: | 1687-8019 |
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