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Development of a surface plasmon resonance and nanomechanical biosensing hybrid platform for multiparametric reading

AuthorsÁlvarez, Mar ; Fariña, David ; Escuela, Alfonso M.; Sendra, José Ramón; Lechuga, Laura M.
Issue Date2013
PublisherAmerican Institute of Physics
CitationReview of Scientific Instruments 84(1): 015008 (2013)
AbstractWe have developed a hybrid platform that combines two well-known biosensing technologies based on quite different transducer principles: surface plasmon resonance and nanomechanical sensing. The new system allows the simultaneous and real-time detection of two independent parameters, refractive index change (Δn), and surface stress change (Δσ) when a biomolecular interaction takes place. Both parameters have a direct relation with the mass coverage of the sensor surface. The core of the platform is a common fluid cell, where the solution arrives to both sensor areas at the same time and under the same conditions (temperature, velocity, diffusion, etc.).The main objective of this integration is to achieve a better understanding of the physical behaviour of the transducers during sensing, increasing the information obtained in real time in one single experiment. The potential of the hybrid platform is demonstrated by the detection of DNA hybridization. © 2013 American Institute of Physics.
Publisher version (URL)http://dx.doi.org/10.1063/1.4789430
Identifiersdoi: 10.1063/1.4789430
issn: 0034-6748
e-issn: 1089-7623
Appears in Collections:(CIN2) Artículos
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