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Development of a surface plasmon resonance and nanomechanical biosensing hybrid platform for multiparametric reading

AutorÁlvarez, Mar ; Fariña, David ; Escuela, Alfonso M.; Sendra, José Ramón; Lechuga, Laura M.
Fecha de publicación2013
EditorAmerican Institute of Physics
CitaciónReview of Scientific Instruments 84(1): 015008 (2013)
ResumenWe have developed a hybrid platform that combines two well-known biosensing technologies based on quite different transducer principles: surface plasmon resonance and nanomechanical sensing. The new system allows the simultaneous and real-time detection of two independent parameters, refractive index change (Δn), and surface stress change (Δσ) when a biomolecular interaction takes place. Both parameters have a direct relation with the mass coverage of the sensor surface. The core of the platform is a common fluid cell, where the solution arrives to both sensor areas at the same time and under the same conditions (temperature, velocity, diffusion, etc.).The main objective of this integration is to achieve a better understanding of the physical behaviour of the transducers during sensing, increasing the information obtained in real time in one single experiment. The potential of the hybrid platform is demonstrated by the detection of DNA hybridization. © 2013 American Institute of Physics.
Versión del editorhttp://dx.doi.org/10.1063/1.4789430
URIhttp://hdl.handle.net/10261/99238
DOI10.1063/1.4789430
Identificadoresdoi: 10.1063/1.4789430
issn: 0034-6748
e-issn: 1089-7623
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