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Title

Casein modified gold nanoparticles for future theranostic applications

AuthorsEspinoza-Castañeda, Marisol ; Escosura-Muñiz, Alfredo de la ; Merkoçi, Arben
KeywordsHydrogen evolution electrocatalysis
Theranostic
Caseinglycomacropeptide
Caseinglycopeptide
Bacteria
Gold nanoparticle
Biosensor
Issue Date2013
PublisherElsevier
CitationBiosensors and Bioelectronics 40(1): 271-276 (2013)
AbstractThe synthesis and characterization of gold nanoparticles (AuNPs 20. nm sized) modified with k-casein derived peptides in order to monitor the peptide effect as bacterial adhesion inhibitor, thanks to the carrier/concentrator effect of the AuNPs is here presented. Some aspects related to the stability of AuNP/peptide conjugates for a potential application in the design of an electrochemical biosensor for pathogen bacteria detection are also discussed. This peptide based nanoparticle assay takes advantage of the dual character of the AuNPs: as carrier of the biorecognition molecule and also as electrocatalytic label, allowing the evaluation of the pathogen bacteria-peptide interaction in a simple and rapid way through the chronoamperometric monitoring of the hydrogen evolution reaction on screen-printed carbon electrodes. The developed proof of concept theranostic system may open the way to therapeutic and biosensing applications with interest for various fields. © 2012 Elsevier B.V.
URIhttp://hdl.handle.net/10261/99203
DOI10.1016/j.bios.2012.07.042
Identifiersdoi: 10.1016/j.bios.2012.07.042
issn: 0956-5663
e-issn: 1873-4235
Appears in Collections:(CIN2) Artículos
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