English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/98959
Compartir / Impacto:
Add this article to your Mendeley library MendeleyBASE
Citado 7 veces en Web of Knowledge®  |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)

Structure of tyrosine aminotransferase from Leishmania infantum

Autor Moreno-Izquierdo, Miguel A. ; Abramov, Ariel; Alonso, Ana ; Zhang, S.; Alcolea, Pedro J. ; Edwards, T.; Lorimer, D.; Myler, P. J.; Larraga, Vicente
Fecha de publicación may-2014
EditorInternational Union of Crystallography
Citación Acta Crystallographica Section F (2014) 70 (5) 543–685
ResumenThe trypanosomatid parasite Leishmania infantum is the causative agent of visceral leishmaniasis (VL), which is usually fatal unless treated. VL has an incidence of 0.5 million cases every year and is an important opportunistic co-infection in HIV/AIDS. Tyrosine aminotransferase (TAT) has an important role in the metabolism of trypanosomatids, catalyzing the first step in the degradation pathway of aromatic amino acids, which are ultimately converted into their corresponding l-2-oxoacids. Unlike the enzyme in Trypanosoma cruzi and mammals, L. infantum TAT (LiTAT) is not able to transaminate ketoglutarate. Here, the structure of LiTAT at 2.35 A ° resolution is reported, and it is confirmed that the presence of two Leishmania-specific residues (Gln55 and Asn58) explains, at least in part, this specific reactivity. The difference in substrate specificity between leishmanial and mammalian TAT and the importance of this enzyme in parasite metabolism suggest that it may be a useful target in the development of new drugs against leishmaniasis.
Descripción 5 p.-4 fig.-1 tab.
Versión del editorhttp://dx.doi.org/10.1107/S2053230X14007845
URI http://hdl.handle.net/10261/98959
Aparece en las colecciones: (CIB) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Act, Christalograph. F. Larraga 2014.pdf544,18 kBAdobe PDFVista previa
Mostrar el registro completo

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.