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Genome-wide antisense transcription drives mRNA processing in bacteria

AuthorsLasa, Íñigo ; Toledo-Arana, Alejandro ; Dobin, Alexander; Villanueva, Maite ; Ruiz de los Mozos, Igor ; Vergara-Irigaray, Marta ; Segura, Víctor; Fagegaltier, Delphine; Penadés, José R. ; Valle Turrillas, Jaione ; Solano Goñi, Cristina ; Gingeras, Thomas R.
KeywordsStaphylococcus aureus
Antisense RNAs
Overlapping transcription
Issue DateDec-2012
CitationCell Symposia. Functional RNAs (2012)
AbstractAntisense transcripts are RNA molecules that map in an overlapping fashion to the complementary strand of sense strand transcript. Their function in regulating gene expresssion is recognized but considered to be restricted to a limited number of genes in an organism. Here, we describe a genome-wide use of antisense transcription in Gram-positive bacteria to process sense transcripts by means of creating double stranded substrates for RNase III endoribonuclease.
DescriptionTrabajo presentado en el Cell Symposia. Functional RNAs, celebrado en Sitges (España) del 2 al 4 de diciembre de 2012.
Appears in Collections:(IDAB) Comunicaciones congresos
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