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Title

Synthesis of hyaluronic acid oligosaccharides and exploration of a fluorous-assisted approach

AuthorsMacchione, Giuseppe ; de Paz, José L.; Nieto, Pedro M.
KeywordsHyaluronic acid
Glycosylation
Fluorous tag
Oligosaccharide synthesis
Glucuronic acid
Carbohydrates
Issue Date2014
PublisherElsevier
CitationCarbohydrate Research, 395: 17-25 (2014)
AbstractThe synthesis of hyaluronic acid oligomers (tri- and tetrasaccharide) is described. We have followed a pre-glycosylation oxidation strategy. Glucuronic acid units were directly employed in coupling reactions with suitably protected glucosamine derivatives. In order to simplify the purification of synthetic intermediates, a fluorous-assisted strategy has been also explored. Using this approach, a hyaluronic acid trisaccharide was prepared.
Publisher version (URL)http://dx.doi.org/10.1016/j.carres.2014.05.007
URIhttp://hdl.handle.net/10261/98747
DOI10.1016/j.carres.2014.05.007
Appears in Collections:(IIQ) Artículos
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