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Prevalence of HIV-1 dual infection in long-term nonprogressor-elite controllers

AuthorsPernas, María; Val, Margarita del ; López-Galíndez, Cecilio
Issue Date2013
PublisherLippincott Williams & Wilkins
CitationJournal of Acquired Immune Deficiency Syndromes 64: 225- 231 (2013)
AbstractINTRODUCTION: Human immunodeficiency virus type 1 (HIV-1) dual infection (DI) in long-term nonprogressor-elite controller patients (LTNP-EC) has been described only in sporadic cases and then, consequences in disease progression are not clearly established. To fill-up this limited knowledge, we analyzed, for the first time, the prevalence, host genetic polymorphisms, and clinical consequences of HIV-1 DI in a group of LTNP-EC. METHODS: For DI detection, nucleotide sequences in env gene from viruses from 20 LTNP-EC were analyzed by maximum likelihood. Epidemiological and clinical parameters and host factors of patients were also studied. RESULTS: DI was detected in 4 (20%) of the 20 LTNP-EC, of which 3 maintained the elite controller status. CD4 T-cell counts were not different between single and DI patients although higher CD8 T-cell counts were observed in DI patients, and, consequently, the CD4/CD8 ratios were lower in LTNP-EC DI patients. CONCLUSIONS: Prevalence of HIV-1 DIs in LTNP-EC is similar to other groups of HIV-1 patients; in addition, DI was not associated with loss of disease control in the patients. These DI LTNP-EC patients showed, in comparison with single infected patients, higher numbers of CD8 T cells and lower CD4/CD8 ratios. Copyright © 2013 by Lippincott Williams & Wilkins.
Identifiersdoi: 10.1097/QAI.0b013e31829bdc85
issn: 1525-4135
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