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Título

Non-coding RNAs in the development of sensory organs and related diseases

Autor Conte, Iván; Banfi, Sandro; Bovolenta, Paola
Palabras clave Eye
Olfactory system
Inner ear
Long non-coding RNA
MicroRNA
Fecha de publicación 2013
EditorBirkhäuser Verlag
Citación Cellular and Molecular Life Sciences 70: 4141- 4155 (2013)
ResumenGenomes are transcribed well beyond the conventionally annotated protein-encoding genes and produce many thousands of regulatory non-coding RNAs (ncRNAs). In the last few years, ncRNAs, especially microRNAs and long non-coding RNA, have received increasing attention because of their implication in the function of chromatin-modifying complexes and in the regulation of transcriptional and post-transcriptional events. The morphological events and the genetic networks responsible for the development of sensory organs have been well delineated and therefore sensory organs have provided a useful scenario to address the role of ncRNAs. In this review, we summarize the current information on the importance of microRNAs and long non-coding RNAs during the development of the eye, inner ear, and olfactory system in vertebrates. We will also discuss those cases in which alteration of ncRNA expression has been linked to pathological conditions affecting these organs. © 2013 Springer Basel.
URI http://hdl.handle.net/10261/98173
DOI10.1007/s00018-013-1335-z
Identificadoresdoi: 10.1007/s00018-013-1335-z
issn: 1420-682X
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