English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/98164
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Nitrosothiols in the immune system: Signaling and protection

AuthorsHernansanz-Agustín, Pablo; Izquierdo-Álvarez, Alicia; García-Ortiz, Alicia; Ibiza, Sales; Serrador, Juan M. ; Martínez Ruiz, Antonio
Issue Date2013
PublisherMary Ann Liebert
CitationAntioxidants and Redox Signaling 18: 288- 308 (2013)
AbstractSignificance: In the immune system, nitric oxide (NO) has been mainly associated with antibacterial defenses exerted through oxidative, nitrosative, and nitrative stress and signal transduction through cyclic GMP-dependent mechanisms. However, S-nitrosylation is emerging as a post-translational modification (PTM) involved in NO-mediated cell signaling. Recent Advances: Precise roles for S-nitrosylation in signaling pathways have been described both for innate and adaptive immunity. Denitrosylation may protect macrophages from their own S-nitrosylation, while maintaining nitrosative stress compartmentalized in the phagosomes. Nitrosothiols have also been shown to be beneficial in experimental models of autoimmune diseases, mainly through their role in modulating T-cell differentiation and function. Critical Issues: Relationship between S-nitrosylation, other thiol redox PTMs, and other NO-signaling pathways has not been always taken into account, particularly in the context of immune responses. Methods for assaying S-nitrosylation in individual proteins and proteomic approaches to study the S-nitrosoproteome are constantly being improved, which helps to move this field forward. Future Directions: Integrated studies of signaling pathways in the immune system should consider whether S-nitrosylation/denitrosylation processes are among the PTMs influencing the activity of key signaling and adaptor proteins. Studies in pathophysiological scenarios will also be of interest to put these mechanisms into broader contexts. Interventions modulating nitrosothiol levels in autoimmune disease could be investigated with a view to developing new therapies. © 2013, Mary Ann Liebert, Inc.
Identifiersdoi: 10.1089/ars.2012.4765
issn: 1523-0864
Appears in Collections:(CBM) Artículos
Files in This Item:
File Description SizeFormat 
JM_Serrador_Antix_Redox_Sign.pdf865,57 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.