English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/9775
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 43 veces en Web of Knowledge®  |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)
Título

Infectious bursal disease virus is an icosahedral polyploid dsRNA virus

Autor Luque Buzo, Daniel; Rivas, Germán ; Alfonso, Carlos ; Carrascosa, José L.; Rodríguez Aguirre, José F.; Ruiz Castón, José
Palabras clave Cargo volume
Infectious bursal disease virus (IBDV)
Icosahedral dsRNA viruses
Life cycle
Viral polyploidy
Fecha de publicación 21-ene-2009
EditorNational Academy of Sciences (U.S.)
Citación Proc. Natl. Acad. Sci. USA, doi: 10.1073/pnas.0808498106
ResumenViruses are a paradigm of the economy of genome resources, reflected in their multiplication strategy and for their own structure. Although there is enormous structural diversity, the viral genome is always enclosed within a proteinaceous coat, and most virus species are haploid; the only exception to this rule are the highly pleomorphic enveloped viruses. We performed an in-depth characterization of infectious bursal disease virus (IBDV), a non-enveloped icosahedral dsRNA virus with a bisegmented genome. Up to 6 natural populations can be purified, which share a similar protein composition but show higher sedimentation coefficients as particle density increases. Stoichiometry analysis of their genome indicated that these biophysical differences correlate with the copy number of dsRNA segments inside the viral capsid. This is a demonstration of a functional polyploid icosahedral dsRNA virus. We show that IBDV particles with greater genome copy number have higher infectivity rates. Our results show an unprecedented replicative strategy for dsRNA viruses and suggest that birnaviruses are living viral entities encompassing numerous functional and structural characteristics of positive and negative ssRNA viruses.
Descripción Supplementary information (Suppl. figures S1-S3, suppl. tables S1-S2, 5 pages) available at: http://www.pnas.org/content/suppl/2009/01/20/0808498106.DCSupplemental/0808498106SI.pdf
Versión del editorhttp://dx.doi.org/10.1073/pnas.0808498106
URI http://hdl.handle.net/10261/9775
DOI10.1073/pnas.0808498106
ISSN0027-8424
Aparece en las colecciones: (CIB) Artículos
(CNB) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.