English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/97652
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Hedgehog On The Move: A Precise Spatial Control Of Hedgehog Dispersion Shapes The Gradient

AuthorsGradilla, Ana-Citlali ; Guerrero Vega, Isabel
Issue Date2013
PublisherElsevier
CitationCurrent Opinion in Genetics and Development 23: 363- 373 (2013)
AbstractHedgehog (Hh) as morphogen directs cell differentiation during development activating various target genes in a concentration dependent manner. The mechanisms that permit controlled Hh dispersion and gradient formation remain controversial. New research in the Drosophila wing disc epithelium has revealed a crucial role of Hh recycling for its release and transportation from source cells. Lipid modifications on Hh mediate key interactions with different elements of the pathway, which balance the retention and release of the molecule through the basolateral side of the epithelium, allowing its tight spatial control. Dispersion of Hh is also determined by its hydrophobic nature, and the mechanisms that include membrane-tethered transport of Hh are increasingly proposed. © 2013 Elsevier Ltd.
URIhttp://hdl.handle.net/10261/97652
DOI10.1016/j.gde.2013.04.011
Identifiersdoi: 10.1016/j.gde.2013.04.011
issn: 0959-437X
Appears in Collections:(CBM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.