English
español
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10261/97618
Share/Impact:
Statistics |
![]() ![]() ![]() |
|
|
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |||
|
Title: | Fungal infection in cerebrospinal fluid from some patients with multiple sclerosis |
Authors: | Pisa, Diana ![]() ![]() ![]() |
Issue Date: | 2013 |
Publisher: | Springer |
Citation: | European Journal of Clinical Microbiology and Infectious Diseases 32: 795- 801 (2013) |
Abstract: | Multiple sclerosis (MS) is the prototypical inflammatory disease of the central nervous system and spinal cord, leading to axonal demyelination of neurons. Recently, we have found a correlation between fungal infection and MS in peripheral blood of patients. The present work provides evidence of fungal infection in the cerebrospinal fluid (CSF) of some MS patients. Thus, fungal antigens can be demonstrated in CSF, as well as antibodies reacting against several Candida species. Comparison was made between CSF and blood serum for the presence of fungal antigens (proteins) and antibodies against different Candida spp. Analyses of both CSF and serum are complementary and serve to better evaluate for the presence of disseminated fungal infection. In addition, PCR analyses indicate the presence of DNA from different fungal species in CSF, depending on the patient analyzed. Overall, these findings support the notion that fungal infection can be demonstrated in CSF from some MS patients. This may constitute a risk factor in this disease and could also help in understanding the pathogenesis of MS. © 2013 Springer-Verlag Berlin Heidelberg. |
URI: | http://hdl.handle.net/10261/97618 |
DOI: | http://dx.doi.org/10.1007/s10096-012-1810-8 |
Identifiers: | doi: 10.1007/s10096-012-1810-8 issn: 0934-9723 |
Appears in Collections: | (CBM) Artículos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | ![]() View/Open |
Show full item record
Review this work
Review this work
WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.