English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/97614
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 33 veces en Web of Knowledge®  |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)
Título

Function of oncogenes in cancer development: A changing paradigm

Autor Vicente-Dueñas, Carolina; Romero-Camarero, Isabel; Cobaleda, César; Sánchez García, Isidro
Palabras clave Tumoural reprogramming
Oncogenes
Mouse model
Cancer therapy
Cancer stem cell
Fecha de publicación 2013
EditorEuropean Molecular Biology Organization
Citación EMBO Journal 32(11): 1502-1513 (2013)
ResumenTumour-associated oncogenes induce unscheduled proliferation as well as genomic and chromosomal instability. According to current models, therapeutic strategies that block oncogene activity are likely to selectively target tumour cells. However, recent evidences have revealed that oncogenes are only essential for the proliferation of some specific tumour cell types, but not all. Indeed, the latest studies of the interactions between the oncogene and its target cell have shown that oncogenes contribute to cancer development not only by inducing proliferation but also by developmental reprogramming of the epigenome. This provides the first evidence that tumorigenesis can be initiated by stem cell reprogramming, and uncovers a new role for oncogenes in the origin of cancer. Here we analyse these evidences and propose an updated model of oncogene function that can explain the full range of genotype-phenotype associations found in human cancer. Finally, we discuss how this vision opens new avenues for developing novel anti-cancer interventions. © 2013 European Molecular Biology Organization.
URI http://hdl.handle.net/10261/97614
DOI10.1038/emboj.2013.97
Identificadoresissn: 0261-4189
Aparece en las colecciones: (IBMCC) Artículos
(CBM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.