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Effect of bicellar systems on skin properties

AuthorsBarbosa-Barros, Lucyana ; Barba, Clara ; Cocera Núñez, Mercedes ; Coderch Negra, M. Luisa ; López-Iglesias, Carmen; Maza, Alfons de la ; López Serrano, Olga
KeywordsFreeze-substitution transmission electron microscopy
Skin hydration
Biophysical properties of skin
Stratum corneum permeability
Stratum corneum microstructure
Issue Date22-Oct-2007
CitationInternational Journal of Pharmaceutics 352(1-2): 263-272 (2007)
AbstractBicelles are discoidal aggregates formed by a flat dimyristoyl-glycero-phosphocholine (DMPC) bilayer, stabilized by a rim of dihexanoylglycero-phosphocholine (DHPC) in water. Given the structure, composition and the dimensions of these aggregates around 10–50 nm diameter, their use for topical applications is a promising strategy. This work evaluates the effect of DMPC/DHPC bicelles with molar ratio (2/1) on intact skin. Biophysical properties of the skin, such as transepidermal water loss (TEWL), elasticity, skin capacitance and irritation were measured in healthy skin in vivo. To study the effect of the bicellar systems on the microstructure of the stratum corneum (SC) in vitro, pieces of native tissue were treated with the aforementioned bicellar system and evaluated by freeze substitution applied to transmission electron microscopy (FSTEM). Our results show that bicelles increase the TEWL, the skin elastic parameters and, decrease skin hydration without promoting local signs of irritation and without affecting the SC lipid microstructure. Thus, a permeabilizing effect of bicelles on the skin takes place possibly due to the changes in the phase behaviour of the SC lipids by effect of phospholipids from bicelles.
Description10 pages, 9 figures.
Publisher version (URL)http://dx.doi.org/10.1016/j.ijpharm.2007.10.012
Appears in Collections:(IQAC) Artículos
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