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Título

Effect of bicellar systems on skin properties

Autor Barbosa-Barros, L.; Barba, Clara; Cócera, Mercè; Coderch Negra, M. Luisa; López-Iglesias, Carmen; Maza, Alfons de la; López Serrano, Olga
Palabras clave Freeze-substitution transmission electron microscopy
Tewl
Skin hydration
Biophysical properties of skin
Stratum corneum permeability
Stratum corneum microstructure
Fecha de publicación 22-oct-2007
EditorElsevier
Citación International Journal of Pharmaceutics 352(1-2): 263-272 (2007)
ResumenBicelles are discoidal aggregates formed by a flat dimyristoyl-glycero-phosphocholine (DMPC) bilayer, stabilized by a rim of dihexanoylglycero-phosphocholine (DHPC) in water. Given the structure, composition and the dimensions of these aggregates around 10–50 nm diameter, their use for topical applications is a promising strategy. This work evaluates the effect of DMPC/DHPC bicelles with molar ratio (2/1) on intact skin. Biophysical properties of the skin, such as transepidermal water loss (TEWL), elasticity, skin capacitance and irritation were measured in healthy skin in vivo. To study the effect of the bicellar systems on the microstructure of the stratum corneum (SC) in vitro, pieces of native tissue were treated with the aforementioned bicellar system and evaluated by freeze substitution applied to transmission electron microscopy (FSTEM). Our results show that bicelles increase the TEWL, the skin elastic parameters and, decrease skin hydration without promoting local signs of irritation and without affecting the SC lipid microstructure. Thus, a permeabilizing effect of bicelles on the skin takes place possibly due to the changes in the phase behaviour of the SC lipids by effect of phospholipids from bicelles.
Descripción 10 pages, 9 figures.
Versión del editorhttp://dx.doi.org/10.1016/j.ijpharm.2007.10.012
URI http://hdl.handle.net/10261/9747
DOI10.1016/j.ijpharm.2007.10.012
ISSN0378-5173
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