Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/97459
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Alcaide, Anna | - |
dc.contributor.author | Llebaria, Amadeu | - |
dc.date.accessioned | 2014-05-30T10:37:53Z | - |
dc.date.available | 2014-05-30T10:37:53Z | - |
dc.date.issued | 2014 | - |
dc.identifier | doi: 10.1021/jo500061w | - |
dc.identifier | issn: 0022-3263 | - |
dc.identifier | e-issn: 1520-6904 | - |
dc.identifier.citation | Journal of Organic Chemistry 79: 2993- 3029 (2014) | - |
dc.identifier.uri | http://hdl.handle.net/10261/97459 | - |
dc.description.abstract | A library of sphingolipid analogues is designed and tested as inhibitors against mammalian and fungal sphingolipid enzymes. The synthesis of sphingolipid analogues is based on the nucleophilic ring-opening reactions of N-activated aziridine derivatives with thiols, β-thioglycosyl thiols, phosphorothioates, phosphates, and amines to afford compounds having different lipid backbones and substituents representative of the naturally occurring sphingolipid families. The screening on mammalian sphingomyelin synthase (SMS) and glucosylceramide synthase (GCS) and yeast inositol phosphorylceramide synthase (IPCS) enzymes identified several inhibitors of GCS and IPCS, but no inhibition of SMS was observed among the tested compounds. © 2014 American Chemical Society. | - |
dc.publisher | American Chemical Society | - |
dc.rights | closedAccess | - |
dc.title | Aziridine ring opening for the synthesis of sphingolipid analogues: Inhibitors of sphingolipid-metabolizing enzymes | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1021/jo500061w | - |
dc.date.updated | 2014-05-30T10:37:53Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
Aparece en las colecciones: | (IQM) Artículos (IQAC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
13
checked on 13-abr-2024
WEB OF SCIENCETM
Citations
11
checked on 25-feb-2024
Page view(s)
305
checked on 22-abr-2024
Download(s)
130
checked on 22-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.