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Title

A study on the influence of emulsion droplet size on the skin penetration of tetracaine

AuthorsIzquierdo, P.; Wiechers, J. W.; Escribano, E.; García-Celma, M. J. ; Tadros, Tharwat F.; Esquena, Jordi ; Dederen, Joseph C.; Solans, Conxita
KeywordsSkin penetration
Tetracaine
Nano-emulsion
Emulsion droplet size
Dermal delivery
Transdermal delivery
Percutaneous absorption
Issue Date17-Jul-2007
PublisherS. Karger AG
CitationSkin Pharmacology and Physiology 20(5): 263-270 (2007)
Abstract[Objectives/Aims] The influence of emulsion droplet size on the skin penetration of a model drug, tetracaine, was studied. For this purpose, in vitro dermal and transdermal delivery of tetracaine from 6 emulsions (3 macro-emulsions with droplet sizes > 1μm and 3 nano-emulsions with droplet sizes < 100 nm) were tested.
[Methods] Two approaches were used: in the first one, the composition of the emulsions was kept constant, while in the second one, the surfactant concentration in the aqueous phase was kept constant by varying the overall surfactant concentration.
[Results] The results from emulsions differing only in droplet size did not provide statistically significant evidence for the anticipated increase in transdermal or dermal delivery (after 24 h) when reducing emulsion droplet size. The same results were obtained when the surfactant concentration in the aqueous phase was kept constant, indicating that there is no influence of emulsion droplet size on the skin penetration of tetracaine within the droplet size range studied.
[Conclusion] This is in contrast to what has been reported in various publications that claim penetration to increase with reducing droplet size. It should be noted that the results reported so far are based on emulsions that apart from droplet size also differed in composition and/or system components.
Description8 pages, 4 figures.-- PMID: 17641530 [PubMed].
Publisher version (URL)http://dx.doi.org/10.1159/000106076
URIhttp://hdl.handle.net/10261/9732
DOIhttp://dx.doi.org/10.1159/000106076
ISSN1660-5535
Appears in Collections:(IQAC) Artículos
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