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Title

Biofilm switch and immune response determinants at early stages of infection

AuthorsValle Turrillas, Jaione ; Solano Goñi, Cristina ; García, Begoña ; Toledo-Arana, Alejandro ; Lasa, Íñigo
KeywordsInnate immune response
Chronic infection
Biofilm
c-di-GMP
STING
cGAS
PAMPsType I interferon
Issue Date2013
PublisherElsevier
CitationTrends in Microbiology 21(8): 364-371 (2013)
AbstractBiofilm development is recognized as a major virulence factor underlying most chronic bacterial infections. When a biofilm community is established, planktonic cells growing in the surroundings of a tissue switch to a sessile lifestyle and start producing a biofilm matrix. The initial steps of in vivo biofilm development are poorly characterized and difficult to assess experimentally. A great amount of in vitro evidence has shown that accumulation of high levels of cyclic dinucleotides (c-di-NMPs) is the most prevalent hallmark governing the initiation of biofilm development by bacteria. As mentioned above, recent studies also link detection of c-di-NMPs by host cells with the activation of a type I interferon immune response against bacterial infections. We discuss here c-di-NMP signaling and the host immune response in the context of the initial steps of in vivo biofilm development. © 2013 Elsevier Ltd.
URIhttp://hdl.handle.net/10261/97197
DOI10.1016/j.tim.2013.05.008
Identifiersdoi: 10.1016/j.tim.2013.05.008
issn: 0966-842X
e-issn: 1878-4380
Appears in Collections:(IDAB) Artículos
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