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dc.contributor.author | Ruiz de los Mozos, Igor | - |
dc.contributor.author | Vergara-Irigaray, Marta | - |
dc.contributor.author | Villanueva, Maite | - |
dc.contributor.author | Bitarte, Nerea | - |
dc.contributor.author | Valle Turrillas, Jaione | - |
dc.contributor.author | Solano Goñi, Cristina | - |
dc.contributor.author | Lasa, Íñigo | - |
dc.contributor.author | Toledo-Arana, Alejandro | - |
dc.date.accessioned | 2014-05-26T07:49:13Z | - |
dc.date.available | 2014-05-26T07:49:13Z | - |
dc.date.issued | 2013-12-19 | - |
dc.identifier | doi: 10.1371/journal.pgen.1004001 | - |
dc.identifier | issn: 1553-7390 | - |
dc.identifier | e-issn: 1553-7404 | - |
dc.identifier.citation | PLoS Genetics 9(12): e1004001 (2013) | - |
dc.identifier.uri | http://hdl.handle.net/10261/97191 | - |
dc.description.abstract | The presence of regulatory sequences in the 3′ untranslated region (3′-UTR) of eukaryotic mRNAs controlling RNA stability and translation efficiency is widely recognized. In contrast, the relevance of 3′-UTRs in bacterial mRNA functionality has been disregarded. Here, we report evidences showing that around one-third of the mapped mRNAs of the major human pathogen Staphylococcus aureus carry 3′-UTRs longer than 100-nt and thus, potential regulatory functions. We selected the long 3′-UTR of icaR, which codes for the repressor of the main exopolysaccharidic compound of the S. aureus biofilm matrix, to evaluate the role that 3′-UTRs may play in controlling mRNA expression. We showed that base pairing between the 3′-UTR and the Shine-Dalgarno (SD) region of icaR mRNA interferes with the translation initiation complex and generates a double-stranded substrate for RNase III. Deletion or substitution of the motif (UCCCCUG) within icaR 3′-UTR was sufficient to abolish this interaction and resulted in the accumulation of IcaR repressor and inhibition of biofilm development. Our findings provide a singular example of a new potential post-transcriptional regulatory mechanism to modulate bacterial gene expression through the interaction of a 3′-UTR with the 5′-UTR of the same mRNA. © 2013 Ruiz de los Mozos et al. | - |
dc.publisher | Public Library of Science | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | Base Pairing Interaction between 5′- and 3′-UTRs Controls icaR mRNA Translation in Staphylococcus aureus | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1371/journal.pgen.1004001 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1371/journal.pgen.1004001 | - |
dc.date.updated | 2014-05-26T07:49:13Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.identifier.pmid | 24367275 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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pairing_interaction_Ruiz.pdf | 4,43 MB | Adobe PDF | Visualizar/Abrir |
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