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Activities of polymyxin B and cecropin A-melittin peptide CA(1-8)M(1-18) against a multiresistant strain of Acinetobacter baumannii

AuthorsSaugar, José María; Alarcón, Teresa; López-Hernández, Susana; López-Brea, Manuel; Andreu, David; Rivas, Luis
Issue DateMar-2002
PublisherAmerican Society for Microbiology
CitationAntimicrobial Agents and Chemotherapy 46 (3) 875- 878 (2002)
AbstractPolymyxin B (PXB) and the cecropin A-melittin hybrid CA(1-8)M(1-18) (KWKLFKKIGIGAVLKVLTTGLPALIS-NH2) were compared for antibiotic activity on reference and multiresistant Acinetobacter baumannii strains. Significant differences for both peptides were observed on their inner membrane interaction and inhibition by environmental factors, supporting the use of CA(1-8)M(1-18) as a potential alternative to PXB against Acinetobacter.
Publisher version (URL)http://dx.doi.org/10.1128/AAC.46.3.875-878.2002
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