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An effort to make sense of antisense transcription in bacteria

AuthorsLasa, Íñigo ; Toledo-Arana, Alejandro ; Gingeras, Thomas R.
KeywordsOverlapping transcription
RNA processing
Issue Date1-Aug-2012
PublisherLandes Bioscience
CitationRNA Biology 9(8): 1039-1044 (2012)
AbstractAnalysis of bacterial transcriptomes have shown the existence of a genome-wide process of overlapping transcription due to the presence of antisense RNAs, as well as mRNAs that overlapped in their entire length or in some portion of the 5′- and 3′-UTR regions. The biological advantages of such overlapping transcription are unclear but may play important regulatory roles at the level of transcription, RNA stability and translation. In a recent report, the human pathogen Staphylococcus aureus is observed to generate genome-wide overlapping transcription in the same bacterial cells leading to a collection of short RNA fragments generated by the endoribonuclease III, RNase III. This processing appears most prominently in Gram-positive bacteria. The implications of both the use of pervasive overlapping transcription and the processing of these double stranded templates into short RNAs are explored and the consequences discussed. © 2012 Landes Bioscience.
Publisher version (URL)http://dx.doi.org/10.4161/rna.21167
Identifiersdoi: 10.4161/rna.21167
issn: 1547-6286
e-issn: 1555-8584
Appears in Collections:(IDAB) Artículos
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