In vitro bactericidal activity of the antiprotozoal drug miltefosine against Streptococcus pneumoniae and other pathogenic streptococci

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Title:	In vitro bactericidal activity of the antiprotozoal drug miltefosine against Streptococcus pneumoniae and other pathogenic streptococci
Authors:	Llull, Daniel ; Rivas, Luis ; García, Ernesto
Issue Date:	May-2007
Publisher:	American Society for Microbiology
Citation:	Antimicrobial Agents and Chemotherapy 51(5) 1844- 1848 (2007)
Abstract:	Miltefosine (hexadecylphosphocholine), the first oral drug against visceral leishmaniasis, triggered pneumococcal autolysis at concentrations higher than 2.5 μM. Bactericidal activity was also observed in cultures of other streptococci, although these failed to undergo lysis. The autolysis elicited by miltefosine can be attributed to triggering of the pneumococcal autolysin LytA. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Publisher version (URL):	http://dx.doi.org/10.1128/AAC.01428-06
URI:	http://hdl.handle.net/10261/97029
DOI:	10.1128/AAC.01428-06
ISSN:	0066-4804
Appears in Collections:	(CIB) Artículos

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