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Title: | Proteomic mapping of the lung vascular endothelial cell surface in Schistosoma bovis-infected hamsters |
Authors: | Torre Escudero, Eduardo de la ![]() ![]() ![]() ![]() |
Keywords: | Schistosoma bovis Schistosomula Pulmonary vasculature Endothelium Proteome |
Issue Date: | 2014 |
Publisher: | Elsevier |
Citation: | Journal of Proteomics 106: 86–98 (2014) |
Abstract: | Schistosomes are blood trematodes that are perfectly adapted to living in their intravascular habitat and to achieve this they have developed mechanisms enabling them to evade the immune and haemostatic responses of the host and to regulate endothelial cell function to favour their own survival. The objective of this work was to analyse the changes induced by Schistosoma bovis schistosomula in the proteome expressed by infected hamsters, over 10 and 20 days, on the endothelial surface of their pulmonary vasculature. To accomplish this, we subjected the lungs of non-infected and S. bovis-infected hamsters to vascular perfusion with a biotin ester reactive. Analysis by liquid chromatography and tandem mass spectrometry analysis (LC–MS/MS) of endothelial surface proteins resulted in the identification of a total of 459 non-redundant proteins in the lung vasculature of infected and non-infected hamsters. Here we report the proteins identified, classified according to their biological function and cellular location, further analysing the differences in lung vascular proteomes between non-infected and S. bovis-infected hamsters for ten and twenty days. This work provides the first data on the vascular surface proteome of the lung after S. bovis infection and identifies some of the changes induced in it during infection. |
Description: | 46 páginas, 6 figuras, 3 tablas.--The definitive version is available at http://www.elsevier.com |
Publisher version (URL): | http://dx.doi.org/10.1016/j.jprot.2014.04.025 |
URI: | http://hdl.handle.net/10261/96980 |
DOI: | http://dx.doi.org/10.1016/j.jprot.2014.04.025 |
ISSN: | 1874-3919 |
E-ISSN: | 1876-7737 |
Appears in Collections: | (IRNASA) Artículos |
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Proteomic mapping of the lung vascular endothelial cell surface in Schistosoma bovis-infected hamsters.pdf | 356,34 kB | Adobe PDF | ![]() View/Open |
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