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Ring1b bookmarks genes in pancreatic embryonic progenitors for repression in adult β cells

AuthorsArensbergen, Jorin van; García-Hurtado, Javier; Maestro, Miguel Ángel; Correa-Tapia, Miguel; Rutter, Guy A.; Vidal, Miguel ; Ferrer, Jorge
pancreatic b cells
cellular programming
Issue Date2013
PublisherCold Spring Harbor Laboratory Press
CitationGenes and Development 27: 52- 63 (2013)
AbstractPolycomb-mediated gene repression is essential for embryonic development, yet its precise role in lineage-specific programming is poorly understood. Here we inactivated Ring1b, encoding a polycomb-repressive complex 1 subunit, in pancreatic multipotent progenitors (Ring1bprogKO). This caused transcriptional derepression of a subset of direct Ring1b target genes in differentiated pancreatic islet cells. Unexpectedly, Ring1b inactivation in differentiated islet β cells (Ring1bβKO) did not cause derepression, even after multiple rounds of cell division, suggesting a role for Ring1b in the establishment but not the maintenance of repression. Consistent with this notion, derepression in Ring1bprogKO islets occurred preferentially in genes that were targeted de novo by Ring1b during pancreas development. The results support a model in which Ring1b bookmarks its target genes during embryonic development, and these genes are maintained in a repressed state through Ring1b-independent mechanisms in terminally differentiated cells. This work provides novel insights into how epigenetic mechanisms contribute to shaping the transcriptional identity of differentiated lineages. © 2013 by Cold Spring Harbor Laboratory Press.
Publisher version (URL)http://dx.doi.org/10.1101/gad.206094.112
Identifiersissn: 0890-9369
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(CIB) Artículos
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