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Título

Hemolysis and antihemolysis induced by amino acid-based surfactants

Autor Sánchez, Lourdes; Martínez, Verónica; Infante, María Rosa; Mitjans, Montserrat; Vinardell, M. Pilar
Palabras clave Amino acid-based surfactants
Hypotonic hemolysis
Plasma membrane
Volume expansion
Erythrocytes
Fecha de publicación 17-ene-2007
EditorElsevier
Citación Toxicology Letters 169(2): 177-184 (2007)
ResumenSurfactants have the special ability to interact with the lipid bilayer of cell membranes. The red blood cell is one of the most used cellular membrane models to study the mechanisms underlying surfactant-induced osmotic cell resistance. To increase our knowledge regarding the mechanisms of surfactant membrane interaction, we studied the action of five lysine-derivative anionic and three arginine-derivative cationic amino acid-based surfactants on hypotonic hemolysis. Results showed two different antihemolytic behaviors among amino acid-based surfactants, both related to the maximal protective concentration. How the physico-chemical properties and structure of these compounds determine the protection against hypotonic hemolysis is discussed in detail. We found a good correlation between the CMC and the concentrations resulting in maximum protection against hypotonic hemolysis for the cationic surfactants, but no correlation for the anionic surfactants. In the case of lysine derivative surfactants, which only differ in their counterions, the counterion is implicated in the differences in the antihemolytic potency and the hemolytic activities of this.
Descripción 8 pages, 3 figures.-- PMID: 17293064 [PubMed].-- Printed version published on Mar 8, 2007.
Versión del editorhttp://dx.doi.org/10.1016/j.toxlet.2007.01.003
URI http://hdl.handle.net/10261/9645
DOI10.1016/j.toxlet.2007.01.003
ISSN0378-4274
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