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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Camas, F.M. | - |
dc.contributor.author | Alm, E.J. | - |
dc.contributor.author | Poyatos, Juan F. | - |
dc.date.accessioned | 2014-05-07T11:50:51Z | - |
dc.date.available | 2014-05-07T11:50:51Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | PLoS Computational Biology 6 (2010) | - |
dc.identifier.issn | 1553-734X | - |
dc.identifier.uri | http://hdl.handle.net/10261/96331 | - |
dc.description.abstract | The specific binding of regulatory proteins to DNA sequences exhibits no clear patterns of association between amino acids (AAs) and nucleotides (NTs). This complexity of protein-DNA interactions raises the question of whether a simple set of wide-coverage recognition rules can ever be identified. Here, we analyzed this issue using the extensive LacI family of transcriptional factors (TFs). We searched for recognition patterns by introducing a new approach to phylogenetic footprinting, based on the pervasive presence of local regulation in prokaryotic transcriptional networks. We identified a set of specificity correlations -determined by two AAs of the TFs and two NTs in the binding sites- that is conserved throughout a dominant subgroup within the family regardless of the evolutionary distance, and that act as a relatively consistent recognition code. The proposed rules are confirmed with data of previous experimental studies and by events of convergent evolution in the phylogenetic tree. The presence of a code emphasizes the stable structural context of the LacI family, while defining a precise blueprint to reprogram TF specificity with many practical applications © 2010 Camas et al. | - |
dc.description.sponsorship | This work was supported by a Spanish Government Formación de Profesorado Universitario fellowship (to F.M.C.), Ministerio de Ciencia e Innovación grant BFU2008-03632/BMC (to J.F.P), and Comunidad de Madrid grant CCG08-CSIC/SAL-3651 (to J.F.P). | - |
dc.publisher | Public Library of Science | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | Local gene regulation details a recognition code within the laci transcriptional factor family | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1371/journal.pcbi.1000989 | - |
dc.date.updated | 2014-05-07T11:50:51Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.identifier.pmid | 21085639 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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PloS Computational Biology.pdf | 1,14 MB | Adobe PDF | Visualizar/Abrir |
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