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Antitags: SERS-encoded nanoparticle assemblies that enable single-spot multiplex protein detection

AuthorsGuarrotxena, Nekane ; Bazan, Guillermo C.
Issue Date2014
CitationAdvanced Materials 26: 1941- 1946 (2014)
AbstractSimultaneous detection of multiple proteins on a single spot can be efficiently achieved by using multiplexed surface-enhanced Raman spectroscopy (SERS)-encoded nanoparticle 'antitags' consisting of poly(ethylene glycol) (PEG)-protected silver dimers (and higher aggregates) and antibody-tagging entities. The effective SERS-based multivariate deconvolution approach guarantees an accurate and successful distinguishable identification of single and multiple proteins in complex samples. Their potential application in multiplexed SERS bioimaging technology can be easily envisaged. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Identifiersdoi: 10.1002/adma.201304107
issn: 1521-4095
e-issn: 1521-4095
Appears in Collections:(ICTP) Artículos
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