English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/96185
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Epigenetics of Sex Determination and Gonadogenesis

AutorPiferrer, Francesc
Palabras clavePolycomb/trithorax
Non-coding RNAs
Histone modification
DNA methylation
Disorders of sexual development
Control of reproduction
Global change
Sex differentiation
Fecha de publicaciónabr-2013
EditorAmerican Association of Anatomists
CitaciónDevelopmental Dynamics 242(4): 360-370 (2013)
ResumenEpigenetics is commonly defined as the study of heritable changes in gene function that cannot be explained by changes in DNA sequence. The three major epigenetic mechanisms for gene expression regulation include DNA methylation, histone modifications, and non-coding RNAs. Epigenetic mechanisms provide organisms with the ability to integrate genomic and environmental information to modify the activity of their genes for generating a particular phenotype. During development, cells differentiate, acquire, and maintain identity through changes in gene expression. This is crucial for sex determination and differentiation, which are among the most important developmental processes for the proper functioning and perpetuation of species. This review summarizes studies showing how epigenetic regulatory mechanisms contribute to sex determination and reproductive organ formation in plants, invertebrates, and vertebrates. Further progress will be made by integrating several approaches, including genomics and Next Generation Sequencing to create epigenetic maps related to different aspects of sex determination and gonadogenesis. Epigenetics will also contribute to understand the etiology of several disorders of sexual development. It also might play a significant role in the control of reproduction in animal farm production and will aid in recognizing the environmental versus genetic influences on sex determination of sensitive species in a global change scenario. Developmental Dynamics 242:360-370, 2013. © 2013 Wiley Periodicals, Inc.
DescripciónSpecial issue Reviews–a peer reviewed forum.-- 11 pages, 1 figure
Versión del editorhttp://dx.doi.org/10.1002/dvdy.23924
Identificadoresdoi: 10.1002/dvdy.23924
issn: 1058-8388
e-issn: 1097-0177
Aparece en las colecciones: (ICM) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo

Artículos relacionados:

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.