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Isoquinoline derivatives as calpain inhibitors.
Dernados de isoquinolina como inhibidores de calpaina.

AuthorsHerradón García, Bernardo ; Chicharro, Roberto ; Arán, Vicente J. ; Alonso Giner, Mercedes
Issue Date22-Jun-2006
CitationEuropean Patent Code: EP 1829 864 A1
Abstract[EN]The invention relates to derivative compounds of partially-reduced isoquinoline with substitution of a sec-butyl group at position 3 with a calpain inhibitor activity. The inventive compound comprises an ester or amide derived from (3-sec-butyl-1-oxo-2,3-dihydro-1H-isoquinolin-4-yliden)-acetic acid and (3-sec-butyl-l-thioxo-2,3-dihydro-1H-isoquinolin-4-yliden)-acetic acid. Compounds having formula I or II can be used in the preventive or therapeutic treatment of a degenerative disease.
[ES]La presente invención se refiere a compuestos derivados de isoquinolina parcialmente reducida con sustitución de un grupo sec-butilo en posición 3 con actividad como inhibidores de calpaina. Un compuesto de la presente invención es un éster o amida derivada del ácido (3-Srec-butil-l-oxo-2,3-dihidro-IH-isoquinolin-4-iliden)-acético y de ácido(3-Srec-butil-l-tioxo-2,3-dihidro-1H-isoquinolin-4-iliden)-acético. Los compuestos de fórmula I o 11 tienen aplicación en el tratamiento preventivo o terapéutico de una enfermedad degenerativa.
DescriptionFiling date: 2005-12-05. -- International Publication Number: WO 2006/064075(20060222).-- Applicant: Consejo Superior de Investigaciones Científicas (CSIC).
Appears in Collections:(IQOG) Patentes
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