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dc.contributor.authorMéndez, Sandra-
dc.contributor.authorMartí, Meritxell-
dc.contributor.authorBarba, Clara-
dc.contributor.authorParra Juez, José Luis-
dc.contributor.authorCoderch Negra, M. Luisa-
dc.date.accessioned2009-01-14T08:44:02Z-
dc.date.available2009-01-14T08:44:02Z-
dc.date.issued2007-01-30-
dc.identifier.citationLangmuir 23(3): 1359-1364 (2007)en_US
dc.identifier.issn1520-5827-
dc.identifier.urihttp://hdl.handle.net/10261/9597-
dc.description6 pages,5 figures.-- PMID: 17241059 [PubMed].-- Available online on Dec 6, 2006.en_US
dc.description.abstractThe composition of internal wool lipids (IWL) resembles that of lipids present in other keratinic tissues such as human hair or the stratum corneum. Advances in the isolation of ceramides from wool and in the characterization of their thermotropic properties could facilitate their application in human skin care treatments. IWL are solvents extracted from wool fibers. Ceramide isolation is carried out by medium-pressure liquid chomatrography. The different fractions obtained were analyzed quantitatively by thin layer chromatography coupled to an automated flame ionization detector and by high-performance thin layer chromatography using a densitometric detector. Two important fractions were isolated: one was a mixture of different ceramides and the other was exclusively made of ceramide 2 (nonhydroxy acid sphingosine [NS]). The thermotropic behavior ofIWLand their isolated fractions were studied by thermogravimetric analysis, differential scanning calorimetry (DSC), and by attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR) methodologies. The transition temperature (Tm) obtained was compared with the results of the IWL extract, stratum corneum lipids, and the values found in the bibliography for isolated ceramides. The Tm obtained for IWL (48°C) was lower than that achieved for SCL (65°C). This discrepancy could be due to the different ceramide pattern and to the larger amounts of free fatty acids present in the IWL extract. Although the isolated ceramides had higher Tm values, they resembled the values reported in the bibliography. The suitability of the fraction composed exclusively of ceramide 2 [NS] for skin applications was confirmed by ATR-FTIR and DSC.en_US
dc.description.sponsorshipWe acknowledge the expert assessment of J. Carilla and technical assistance of A. López in the DSC experiments. The authors acknowledge also the expert support of G. von Knorring.en_US
dc.format.extent19968 bytes-
dc.format.mimetypeapplication/msword-
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsclosedAccessen_US
dc.subjectThermotropic behavioren_US
dc.subjectIsolationen_US
dc.subjectCeramidesen_US
dc.subjectWoolen_US
dc.titleThermotropic behavior of ceramides and their isolation from woolen_US
dc.typeartículoen_US
dc.identifier.doi10.1021/la0621315-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.org/10.1021/la0621315en_US
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