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http://hdl.handle.net/10261/9597
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Méndez, Sandra | - |
dc.contributor.author | Martí, Meritxell | - |
dc.contributor.author | Barba, Clara | - |
dc.contributor.author | Parra Juez, José Luis | - |
dc.contributor.author | Coderch Negra, M. Luisa | - |
dc.date.accessioned | 2009-01-14T08:44:02Z | - |
dc.date.available | 2009-01-14T08:44:02Z | - |
dc.date.issued | 2007-01-30 | - |
dc.identifier.citation | Langmuir 23(3): 1359-1364 (2007) | en_US |
dc.identifier.issn | 1520-5827 | - |
dc.identifier.uri | http://hdl.handle.net/10261/9597 | - |
dc.description | 6 pages,5 figures.-- PMID: 17241059 [PubMed].-- Available online on Dec 6, 2006. | en_US |
dc.description.abstract | The composition of internal wool lipids (IWL) resembles that of lipids present in other keratinic tissues such as human hair or the stratum corneum. Advances in the isolation of ceramides from wool and in the characterization of their thermotropic properties could facilitate their application in human skin care treatments. IWL are solvents extracted from wool fibers. Ceramide isolation is carried out by medium-pressure liquid chomatrography. The different fractions obtained were analyzed quantitatively by thin layer chromatography coupled to an automated flame ionization detector and by high-performance thin layer chromatography using a densitometric detector. Two important fractions were isolated: one was a mixture of different ceramides and the other was exclusively made of ceramide 2 (nonhydroxy acid sphingosine [NS]). The thermotropic behavior ofIWLand their isolated fractions were studied by thermogravimetric analysis, differential scanning calorimetry (DSC), and by attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR) methodologies. The transition temperature (Tm) obtained was compared with the results of the IWL extract, stratum corneum lipids, and the values found in the bibliography for isolated ceramides. The Tm obtained for IWL (48°C) was lower than that achieved for SCL (65°C). This discrepancy could be due to the different ceramide pattern and to the larger amounts of free fatty acids present in the IWL extract. Although the isolated ceramides had higher Tm values, they resembled the values reported in the bibliography. The suitability of the fraction composed exclusively of ceramide 2 [NS] for skin applications was confirmed by ATR-FTIR and DSC. | en_US |
dc.description.sponsorship | We acknowledge the expert assessment of J. Carilla and technical assistance of A. López in the DSC experiments. The authors acknowledge also the expert support of G. von Knorring. | en_US |
dc.format.extent | 19968 bytes | - |
dc.format.mimetype | application/msword | - |
dc.language.iso | eng | en_US |
dc.publisher | American Chemical Society | en_US |
dc.rights | closedAccess | en_US |
dc.subject | Thermotropic behavior | en_US |
dc.subject | Isolation | en_US |
dc.subject | Ceramides | en_US |
dc.subject | Wool | en_US |
dc.title | Thermotropic behavior of ceramides and their isolation from wool | en_US |
dc.type | artículo | en_US |
dc.identifier.doi | 10.1021/la0621315 | - |
dc.description.peerreviewed | Peer reviewed | en_US |
dc.relation.publisherversion | http://dx.doi.org/10.1021/la0621315 | en_US |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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