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Title

Heterozygous Deficiency of Endoglin Decreases Insulin and Hepatic Triglyceride Levels during High Fat Diet

AuthorsBeiroa, Daniel; Romero-Picó, Amparo; Langa, Carmen ; Bernabéu, Carmelo ; López, Miguel; López-Novoa, José M.; Nogueiras, Rubén; Diéguez, Carlos
KeywordsMetabolism
Lipids
Insulin
TGF-beta
Liver
Endoglin
Issue Date15-Jan-2013
PublisherPublic Library of Science
CitationPLoS ONE 8(1): e54591
AbstractEndoglin is a transmembrane auxiliary receptor for transforming growth factor-beta (TGF-beta) that is predominantly expressed on proliferating endothelial cells. It plays a wide range of physiological roles but its importance on energy balance or insulin sensitivity has been unexplored. Endoglin deficient mice die during midgestation due to cardiovascular defects. Here we report for first time that heterozygous endoglin deficiency in mice decreases high fat diet-induced hepatic triglyceride content and insulin levels. Importantly, these effects are independent of changes in body weight or adiposity. At molecular level, we failed to detect relevant changes in the insulin signalling pathway at basal levels in liver, muscle or adipose tissues that could explain the insulin-dependent effect. However, we found decreased triglyceride content in the liver of endoglin heterozygous mice fed a high fat diet in comparison to their wild type littermates. Overall, our findings indicate that endoglin is a potentially important physiological mediator of insulin levels and hepatic lipid metabolism
Publisher version (URL)http://dx.doi.org/10.1371/journal.pone.0054591
URIhttp://hdl.handle.net/10261/95933
DOIhttp://dx.doi.org/10.1371/journal.pone.0054591
ISSN1932-6203
E-ISSN1932-6203
Appears in Collections:(CIB) Artículos
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