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Different nucleosomal landscapes at early and late replicating origins in Saccharomyces cerevisiae

AuthorsSoriano, Ignacio ; Morafraile, Esther C.; Vázquez, Enrique ; Antequera, Francisco ; Segurado, Mónica
Issue DateApr-2014
PublisherFundación Ramón Areces
CitationCell Proliferation and Genome Integrity International Symposium (2014)
AbstractEukaryotic genomes are replicated during S phase according to a temporal program. Several determinants seem to control the timing of origin firing, including the chromatin environment and epigenetic modifications. By performing high-resolution analysis of genome-wide nucleosome positioning we have identified different chromatin architectures at early and late replication origins. The different nucleosome patterns from early and late origins are already established in G1 and are tightly correlated with the genomic context. Moreover, specific early and late nucleosomal patterns seem to be fixed robustly, even in rpd3 mutants in which histone acetylation and origin timing have been significantly altered. Nevertheless, higher histone acetylation levels correlate with the local modulation of chromatinassociated features, leading to increased origin accessibility. In addition, we conducted parallel analyses of replication and nucleosome dynamics that revealed that origin conformation is modulated during origin activation.
DescriptionTrabajo presentado al International Symposium "Cell Proliferation and Genome Integrity" organizado por la Fundación Ramón Areces y celebrado en Santander del 3 al 4 de abril de 2014.
Publisher version (URL)http://www.symposiumsantander2014.unican.es/cell/Home.html
Appears in Collections:(IBFG) Comunicaciones congresos
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