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ERAP1 in ankylosing spondylitis: Genetics, biology and pathogenetic role

AuthorsÁlvarez-Navarro, Carlos; López de Castro, José A.
Issue Date2013
PublisherLippincott Williams & Wilkins
CitationCurrent Opinion in Rheumatology 25: 419- 425 (2013)
AbstractPURPOSE OF REVIEW: Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an aminopeptidase of the endoplasmic reticulum involved in trimming of peptides to their optimal size for binding to major histocompatibility complex class I molecules. Natural ERAP1 polymorphism resulting in altered enzymatic activity is associated with ankylosing spondylitis, an inflammatory disorder very strongly linked to HLA-B27. RECENT FINDINGS: This review will summarize recent advances in the genetics of ERAP1 association with this disease, in the molecular basis of ERAP1 function and in the mechanism of functional interaction between ERAP1 and HLA-B27. SUMMARY: The findings suggest that the pathogenetic role of ERAP1 in ankylosing spondylitis is due to allotype-dependent alterations of the HLA-B27 peptidome that affect the immunologic and other features of HLA-B27. © 2013 Wolters Kluwer Health / Lippincott Williams & Wilkins.
Identifiersdoi: 10.1097/BOR.0b013e328362042f
issn: 1040-8711
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