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Title

Deconstructing mitochondrial dysfunction in alzheimer disease

AuthorsGarcía-Escudero, Vega ; Martín-Escudero, Patricia; Perry, George; Ávila, Jesús
Issue Date2013
PublisherHindawi Publishing Corporation
CitationOxidative Medicine and Cellular Longevity (2013)
AbstractThere is mounting evidence showing that mitochondrial damage plays an important role in Alzheimer disease. Increased oxygen species generation and deficient mitochondrial dynamic balance have been suggested to be the reason as well as the consequence of Alzheimer-related pathology. Mitochondrial damage has been related to amyloid-beta or tau pathology or to the presence of specific presenilin-1 mutations. The contribution of these factors to mitochondrial dysfunction is reviewed in this paper. Due to the relevance of mitochondrial alterations in Alzheimer disease, recent works have suggested the therapeutic potential of mitochondrial-targeted antioxidant. On the other hand, autophagy has been demonstrated to play a fundamental role in Alzheimer-related protein stress, and increasing data shows that this pathway is altered in the disease. Moreover, mitochondrial alterations have been related to an insufficient clearance of dysfunctional mitochondria by autophagy. Consequently, different approaches for the removal of damaged mitochondria or to decrease the related oxidative stress in Alzheimer disease have been described. To understand the role of mitochondrial function in Alzheimer disease it is necessary to generate human cellular models which involve living neurons. We have summarized the novel protocols for the generation of neurons by reprogramming or direct transdifferentiation, which offer useful tools to achieve this result. © 2013 Vega García-Escudero et al.
URIhttp://hdl.handle.net/10261/95765
DOI10.1155/2013/162152
Identifiersdoi: 10.1155/2013/162152
issn: 1942-0900
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