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Title

Cytosolic reducing power preserves glutamate in retina

AuthorsDu, Jianhai; Cleghorn, Whitney M.; Contreras, Laura ; Linton, Jonathan; Chan, Guy C.; Chertov, Andrei O.; Saheki, T.; Govindaraju, Viren; Satrústegui, Jorgina ; Hurley, James B.
KeywordsMetabolism
Mitochondria
Glutamate
Neuron
Retina
Issue Date2013
PublisherNational Academy of Sciences (U.S.)
CitationProceedings of the American Academy of Sciences 110: 18501- 18506 (2013)
AbstractGlutamate in neurons is an important excitatory neurotransmitter, but it also is a key metabolite. We investigated how glutamate in a neural tissue is protected from catabolism. Flux analysis using 13C-labeled fuels revealed that retinas use activities of the malate aspartate shuttle to protect >98% of their glutamate from oxidation in mitochondria. Isolation of glutamate from the oxidative pathway relies on cytosolic NADH/NAD+, which is influenced by extracellular glucose, lactate, and pyruvate.
URIhttp://hdl.handle.net/10261/95747
DOI10.1073/pnas.1311193110
Identifiersdoi: 10.1073/pnas.1311193110
issn: 0027-8424
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