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Title

Cytoplasmic TERT Associates to RNA Granules in Fully Mature Neurons: Role in the Translational Control of the Cell Cycle Inhibitor p15INK4B

AuthorsIannilli, Francesca; Zalfa, Francesca; Gärtner, Annette; Bagni, Claudia; Dotti, Carlos G.
Issue Date2013
PublisherPublic Library of Science
CitationPLoS ONE 8 (2013)
AbstractThe main role of Telomerase Reverse Transcriptase (TERT) is to protect telomere length from shortening during cell division. However, recent works have revealed the existence of a pool of TERT associated to mitochondria, where it plays a role in survival. We here show that in fully differentiated neurons the largest pool of cytoplasmic TERT associates to TIA1 positive RNA granules, where it binds the messenger RNA of the cyclin kinase inhibitor p15INK4B. Upon stress, p15INK4B and TERT dissociate and p15INK4B undergoes efficient translation, allowing its pro-survival function. These results unveil another mechanism implicated in the survival of fully differentiated neurons. © 2013 Dotti et al.
URIhttp://hdl.handle.net/10261/95742
DOI10.1371/journal.pone.0066602
Identifiersdoi: 10.1371/journal.pone.0066602
issn: 1932-6203
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